Pseudocatalase cream plus calcium has been developed originally by Schallreuter et al and was used as a substitution for low catalase levels in the treatment of vitiligo (KU Schallreuter et al. Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short term UVB exposure, Dermatology (1995) 190:223-229). The word pseudocatalase has been introduced by these authors to differentiate between the natural enzyme catalase and a chemical complex which does the same job, i.e. degrading hydrogen peroxide (H2O2).

In this context, it is noteworthy that catalase protein cannot penetrate the top layer of the skin. Therefore, any products containing natural catalase in a cream are basically ineffective, and any product advertised as catalase in the treatment of vitiligo should be used with caution.

  • Repigmentation with pseudocatalase cream PC-KUS can be achieved in all skin colours and is independent of the percentage of depigmented skin and the duration of the disease. First signs of repigmentation can be observed after 2-4 months.
  • This treatment modality can also successfully repigment lips, ears and genitals. However, the response on fingers and feet is disappointing. (Schallreuter et al, Dermatology (1995) 190:223-229)
  • The removal of high levels of epidermal H2O2 with narrowband UVB-activated pseudocatalase PC-KUS coincides with stabilization of the depigmentation process followed by repigmentation. (Schallreuter et al, Dermatology (1995) 190:223-229, J Invest Dermatol (2001) 116:167-174, Int J Dermatol (2002) 41:482-487)
  • The treatment has no side effects providing the liver function of the affected individual is normal. (Schallreuter et al, Dermatology (1995) 190: 223-229)
  • A significant faster initiation of repigmentation can be induced with the combination of climatotherapy at the Dead Sea together with pseudocatalase PC-KUS over a period of 21 days. First repigmentation occurs between days 14-20. This fast repigmentation lasts for an additional 3-4 months combined with daily treatment using low-dose narrowband UVB-activated pseudocatalase PC-KUS. This repigmentation is stable! (Schallreuter et al, Int J Dermatol (2002) 41:482-487)
  • The shelf life of pseudocatalase PC-KUS is 2 years, if stored at room temperature (20°C).

Pseudocatalase PC-KUS has been successfully used in over 1000 patients. The drawback is, that this treatment modality is a very disciplined approach and needs an individual treatment plan.

The results are excellent regardless of skin color, age of patient, extent and duration of the disease.


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