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Pseudocatalase cream plus calcium has been developed originally by
Schallreuter et al and was used as a substitution for low catalase
levels in the treatment of vitiligo (KU Schallreuter et al. Treatment
of vitiligo with a topical application of pseudocatalase and calcium
in combination with short term UVB exposure, Dermatology (1995) 190:223-229).
The word pseudocatalase has been introduced by these authors
to differentiate between the natural enzyme catalase and a chemical
complex which does the same job, i.e. degrading hydrogen peroxide
(H2O2).
In
this context, it is noteworthy that catalase protein cannot penetrate
the top layer of the skin. Therefore, any products containing natural
catalase in a cream are basically ineffective, and any product advertised
as catalase in the treatment of vitiligo should be used with caution.
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Repigmentation
with pseudocatalase cream PC-KUS can be achieved in all skin colours
and is independent of the percentage of depigmented skin and the
duration of the disease. First signs of repigmentation can be
observed after 2-4 months.
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This treatment modality can also successfully repigment lips,
ears and genitals. However, the response on fingers and feet is
disappointing.
(Schallreuter et al, Dermatology (1995) 190:223-229)
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The
removal of high levels of epidermal H2O2
with narrowband UVB-activated pseudocatalase PC-KUS coincides
with stabilization of the depigmentation process followed by repigmentation.
(Schallreuter et al, Dermatology (1995) 190:223-229,
J Invest Dermatol (2001) 116:167-174, Int J Dermatol (2002) 41:482-487)
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The
treatment has no side effects providing the liver function of
the affected individual is normal.
(Schallreuter et al, Dermatology (1995) 190: 223-229
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A
significant faster initiation of repigmentation can be induced
with the combination of climatotherapy at the Dead Sea together
with pseudocatalase PC-KUS over a period of 21 days. First repigmentation
occurs between days 14-20. This fast repigmentation lasts for
an additional 3-4 months combined with daily treatment using low-dose
narrowband UVB-activated pseudocatalase PC-KUS. This repigmentation
is stable!
(Schallreuter et al, Int J Dermatol (2002) 41:482-487)
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The
shelf life of pseudocatalase PC-KUS is 2 years, if stored at room
temperature (20°C).
Pseudocatalase
PC-KUS has been successfully used in over 1000 patients. The drawback
is, that this treatment modality is a very disciplined approach.
With our individually
tailored treatment, we can repigment 95% of all affected individuals.
The results are excellent regardless of skin color, age of patient,
extent and duration of the disease.
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Pseudocatalase
COPIES !!!
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