Forschungsgebiete          Publikationen          Aktuell

1.  Schallreuter KU, Moore J, Tobin DJ et al. (1999) alpha-MSH can control the essential cofactor         6-tetrahydrobiopterin in melanogenesis. Ann N Y Acad Sci 885: 329-41

2.  Schallreuter KU (1999) A review of recent advances on the regulation of pigmentation in the human epidermis. Cell Mol Biol (Noisy-le-grand) 45: 943-9

3.  Moore J, Wood JM, Schallreuter KU (1999) Evidence for specific complex formation between alpha-melanocyte stimulating hormone and 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infrared Fourier transform Raman spectroscopy. Biochemistry 38: 15317-24

4.  Schallreuter KU, Moore J, Wood JM et al. (1999) In vivo and in vitro evidence for hydrogen peroxide (H₂O₂) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Invest Dermatol Symp Proc 4: 91-6

5.  Beazley WD, Gaze D, Panske A, Panzig E, Schallreuter KU (1999) Serum selenium levels and blood glutathione peroxidase activities in vitiligo. Br J Dermatol 141: 301-3

6.  Schallreuter KU, Wood JM (1999) The importance of L-phenylalanine transport and its autocrine turnover to L-tyrosine for melanogenesis in human epidermal melanocytes. Biochem Biophys Res Commun 262: 423-8

7.  Schallreuter KU (1999) Successful treatment of oxidative stress in vitiligo. Skin Pharmacol Appl Skin Physiol 12: 132-8

8.  Schallreuter KU (1999) Pseudocatalase treatment in xeroderma pigmentosum: a case report. Br J Dermatol 140: 1190-1

9.  Ancans J, Thody AJ, Wood JM, Beazley WD, Schallreuter KU (1999) Human epidermal proopiomelanocortin (POMC) cDNA variant is identical to mouse POMC cDNA. J Invest Dermatol 112: 516-7

10.  Schallreuter KU (2000) GTP-cyclohydrolase I and vitiligo. Clin Exp Dermatol 25: 655

11.  Behrens-Williams SC, Peters EM, Schallreuter KU (2000) In vivo delayed-type hypersensitivity in 109 patients with vitiligo. Int J Dermatol 39: 593-8

12.  Tobin DJ, Swanson NN, Pittelkow MR, Peters EM, Schallreuter KU (2000) Melanocytes are not absent in lesional skin of long duration vitiligo. J Pathol 191: 407-16

13.  Schallreuter KU, Wood JM (2000) Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol 115: 130-1

14.  Peters EM, Tobin DJ, Seidah NG, Schallreuter KU (2000) Pro-opiomelanocortin-related peptides, prohormone convertases 1 and 2 and the regulatory peptide 7B2 are present in melanosomes of human melanocytes. J Invest Dermatol 114: 430-7

15.  Schallreuter KU, Wood JM (2001) Thioredoxin reductase - its role in epidermal redox status. J Photochem Photobiol B 64: 179-84

16.  Schallreuter KU, Moore J, Wood JM et al. (2001) Epidermal H₂O₂ accumulation alters tetrahydrobiopterin (6BH₄) recycling in vitiligo: identification of a general mechanism in regulation of all 6BH₄-dependent processes? J Invest Dermatol 116: 167-74

17.  Schallreuter KU, Moore J, Behrens-Williams S, Panske A, Harari M (2002) Rapid initiation of repigmentation in vitiligo with Dead Sea climatotherapy in combination with pseudocatalase (PC-KUS). Int J Dermatol 41: 482-7

18.  Schallreuter KU, Tobin DJ, Panske A (2002) Decreased photodamage and low incidence of non-melanoma skin cancer in 136 sun-exposed caucasian patients with vitiligo. Dermatology 204: 194-201

19.  Rokos H, Beazley WD, Schallreuter KU (2002) Oxidative stress in vitiligo: photo-oxidation of pterins produces H₂O₂ and pterin-6-carboxylic acid. Biochem Biophys Res Commun 292: 805-11

20.  Moore J, Wood JM, Schallreuter KU (2002) H₂O₂-mediated oxidation of tetrahydrobiopterin: Fourier transform Raman investigations provide mechanistic implications for the enzymatic utilization and recycling of this essential co-factor. J Raman Spectrosc 33: 610-617

21.  Schallreuter KU, Moore J, Behrens-Williams S et al. (2002) In vitro and in vivo identification of Pseudocatalase activity in Dead Sea water using Fourier Transform Raman Spectroscopy. J Raman Spectrosc 33: 586-592

22.  Marles LK, Peters EM, Tobin DJ, Hibberts NA, Schallreuter KU (2003) Tyrosine hydroxylase isoenzyme I is present in human melanosomes: a possible novel function in pigmentation. Exp Dermatol 12: 61-70

23.  Schallreuter KU, Behrens-Williams S, Khaliq TP et al. (2003) Increased epidermal functioning wild-type p53 expression in vitiligo. Exp Dermatol 12: 268-277

24.  Schallreuter KU, Kothari S, Hasse S et al. (2003) In situ and in vitro evidence for DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes. Biochem Biophys Res Commun 301: 610-616

25.  Kauser S, Schallreuter KU, Thody AJ, Gummer C, Tobin DJ (2003) Regulation of Human Epidermal Melanocyte Biology By beta-Endorphin. J Invest Dermatol 120: 1073-1080

26.  Schallreuter KU (2003) Effectiveness of pseudocatalase formulations in vitiligo. Clin Exp Dermatol 28: 1-2

27.  Schallreuter KU, Kothari S, Elwary S, Rokos H, Hasse S, Panske A (2003) Molecular evidence that halo in Sutton's naevus is not vitiligo. Arch Dermatol Res 295: 223-228

28.  Rokos H, Moore J, Hasse S, Gillbro JM, Wood JM, Schallreuter KU (2004) In vivo Fluorescence Excitation Spectroscopy and in vivo FT-Raman Spectroscopy in human skin: Evidence of H₂O₂ oxidation of epidermal albumin in patients with vitiligo. J Raman Spectrosc 35: 125-130

29.  Schallreuter KU, Elwary SM, Gibbons NC, Rokos H, Wood JM (2004) Activation/deactivation of acetylcholinesterase by H₂O₂: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 315: 502-508

30.  Hasse S, Gibbons NC, Rokos H, Marles LK, Schallreuter KU (2004) Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H₂O₂ stress. J Invest Dermatol 122: 307-313

31.  Elwary SM, Hasse S, Schallreuter KU (2004) m2 muscarinic acetylcholine receptor (mAchR) subtype is present in human epidermal keratinocytes in situ and in vivo. J Invest Dermatol 123: 1206-7

32.  Wood JM, Chavan B, Hafeez I, Schallreuter KU (2004) Regulation of tyrosinase by tetrahydropteridines and H₂O₂. Biochem Biophys Res Commun 325: 1412-7

33.  Kurzen H, Schallreuter KU (2004) Novel aspects in cutaneous biology of acetylcholine synthesis and acetylcholine receptors. Exp Dermatol 13 Suppl 4: 27-30

34.  Schallreuter KU, Wazir U, Kothari S, Gibbons NC, Moore J, Wood JM (2004) Human phenylalanine hydroxylase is activated by H₂O₂: a novel mechanism for increasing the L-tyrosine supply for melanogenesis in melanocytes. Biochem Biophys Res Commun 322: 88-92

35.  Gillbro JM, Marles LK, Hibberts NA, Schallreuter KU (2004) Autocrine catecholamine biosynthesis and the beta-adrenoceptor signal promote pigmentation in human epidermal melanocytes. J Invest Dermatol 123: 346-53

36.  Kauser S, Thody AJ, Schallreuter KU, Gummer CL, Tobin DJ (2004) beta-Endorphin as a regulator of human hair follicle melanocyte biology. J Invest Dermatol 123: 184-95

37.  Schallreuter KU. Basic Research: An Update. In: Lotti T, Hercogova J, eds. Vitiligo. Problems and Solutions. New York: Marcel Decker, 2004: 65-78.

38.  Kauser S, Thody AJ, Schallreuter KU, Gummer CL, Tobin DJ (2005) A fully functional proopiomelanocortin/melanocortin-1 receptor system regulates the differentiation of human scalp hair follicle melanocytes. Endocrinology 146: 532-43

39.  Hasse S, Kothari S, Rokos H, Kauser S, Schürer NY, Schallreuter KU (2005) In vivo and in vitro evidence for autocrine DCoH/HNF-1alpha transcription of albumin in the human epidermis. Exp Dermatol 14: 182-7

40.  Schallreuter KU, Elwary S, Gibbons N, Rokos H, Wood JM (2005) Human epidermal acetylcholinesterase (AchE) is regulated by hydrogen peroxide (H₂O₂). Exp Dermatol 14: 155

41.  Slominski A, Wortsman J, Plonka PM, Schallreuter KU, Paus R, Tobin DJ (2005) Hair follicle pigmentation. J Invest Dermatol 124: 13-21

42.  Schallreuter KU. Vitiligo. In: Hertl M, ed. Autoimmune Diseases of the Skin. Pathogenesis, Diagnosis, Management. 2nd ed. Wien: Springer, 2005: 367-384.

43.  Wood JM, Chavan B, Hafeez I, Schallreuter KU (2005) Regulation of tyrosinase by tetrahydropteridines-What is real? A critical reanalysis of H. Wojtasek's view. Biochem Biophys Res Commun 331: 891-3

44.  Schallreuter KU, Chavan B, Rokos H, Hibberts N, Panske A, Wood JM (2005) Decreased phenylalanine uptake and turnover in patients with vitiligo. Mol Genet Metab 86 Suppl 1: S27-33

45.  Spencer JD, Chavan B, Marles LK, Kauser S, Rokos H, Schallreuter KU (2005) A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin. J Endocrinol 187: 293-302

46.  Schallreuter KU (2005) Oxidative stress in the human epidermis. G Ital Dermatol Venereol 140: 505-14

47.  Wood JM, Schallreuter KU (2006) UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin. J Invest Dermatol 126: 13-4

48.  Schallreuter KU, Rübsam K, Chavan B et al. (2006) Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. Biochem Biophys Res Commun 342: 145-52

49.  Schallreuter KU (2006) Functioning methionine-S-sulfoxide reductases A and B are present in human skin. J Invest Dermatol 126: 947-9

50.  Schallreuter KU, Chiuchiarelli G, Cemeli E et al. (2006) Estrogens can contribute to hydrogen peroxide generation and quinone-mediated DNA damage in peripheral blood lymphocytes from patients with vitiligo. J Invest Dermatol 126: 1036-42

51.  Schallreuter KU, Rokos H (2006) Turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in Asian patients with acute vitiligo. Indian J Dermatol Venereol Leprol 72: 57-9

52.  Hoogduijn MJ, Hitchcock IS, Smit NP, Gillbro JM, Schallreuter KU, Genever PG (2006) Glutamate receptors on human melanocytes regulate the expression of MiTF. Pigment Cell Res 19: 58-67

53.  Elwary SM, Chavan B, Schallreuter KU (2006) The vesicular acetylcholine transporter is present in melanocytes and keratinocytes in the human epidermis. J Invest Dermatol 126: 1879-84

54.  Wood JM, Gibbons NC, Schallreuter KU (2006) Melanocortins in human melanocytes. Cell Mol Biol (Noisy-le-grand) 52: 75-8

55.  Schallreuter KU, Gibbons NCJ, Zothner C, Elwary SM, Rokos H, Wood JM (2006) Butyrylcholinesterase is present in the human epidermis and is regulated by H₂O₂: More evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 349: 931-8

56.  Pey AL, Martinez A, Charubala R et al. (2006) Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. Faseb J 20: 2130-2

57.  Chavan B, Gillbro JM, Rokos H, Schallreuter KU (2006) GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. J Invest Dermatol 126: 2481-9

58.  Schallreuter KU, Gibbons NCJ, Rokos H, Rübsam K, Wood JM (2006) Hydrogen peroxide mediated oxidation severely compromises the methionine sulfoxide A / thioredoxin reductase antioxidant defence system. J Invest Dermatol 126 Suppl 3: Abstract 77

59.  Gibbons NCJ, Wood JM, Rokos H, Schallreuter KU (2006) Computer simulation of native epidermal enzyme structures in the presence and absence of hydrogen peroxide (H2O2):  Potential and pitfalls. J Invest Dermatol 126: 2576-2582

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