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(1999-2011)
1. Schallreuter KU, Moore J, Tobin DJ et al. (1999) alpha-MSH can control the essential
cofactor 6-tetrahydrobiopterin in melanogenesis. Ann N Y Acad Sci
885: 329-41 3. Moore
J,
Wood
JM,
Schallreuter KU (1999) Evidence for specific complex
formation between alpha-melanocyte stimulating hormone and
6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin using near infrared Fourier
transform Raman spectroscopy. Biochemistry 38: 15317-24 4. Schallreuter
KU,
Moore
J,
Wood JM et al. (1999) In vivo and
in vitro evidence for hydrogen peroxide (H2O2)
accumulation
in
the
epidermis of patients with vitiligo and its
successful removal by a UVB-activated pseudocatalase. J Invest Dermatol
Symp Proc 4: 91-6 5. Beazley
WD,
Gaze
D,
Panske A, Panzig E, Schallreuter KU (1999) Serum selenium
levels and blood glutathione peroxidase activities in vitiligo. Br J
Dermatol 141: 301-3 6. Schallreuter
KU,
Wood
JM
(1999) The importance of L-phenylalanine transport and its
autocrine turnover to L-tyrosine for melanogenesis in human epidermal
melanocytes. Biochem Biophys Res Commun 262: 423-8 7. Schallreuter
KU
(1999)
Successful
treatment of oxidative stress in vitiligo. Skin
Pharmacol Appl Skin Physiol 12: 132-8 8. Schallreuter
KU
(1999)
Pseudocatalase
treatment in xeroderma pigmentosum: a case
report. Br J Dermatol 140: 1190-1 9. Ancans J, Thody AJ, Wood JM, Beazley WD,
Schallreuter KU (1999) Human epidermal proopiomelanocortin (POMC) cDNA
variant is identical to mouse POMC cDNA. J Invest Dermatol 112: 516-7 10. Schallreuter KU (2000)
GTP-cyclohydrolase I and vitiligo. Clin Exp Dermatol 25: 655 11. Behrens-Williams SC,
Peters EM, Schallreuter KU (2000) In vivo delayed-type hypersensitivity
in 109 patients with vitiligo. Int J
Dermatol 39: 593-8 12. Tobin
DJ,
Swanson
NN,
Pittelkow MR, Peters EM, Schallreuter KU (2000)
Melanocytes are not absent in lesional skin of long duration vitiligo.
J Pathol 191: 407-16 13. Schallreuter KU, Wood JM (2000) Downregulation
of tyrosinase activity in human melanocyte cell cultures by yohimbine.
J Invest Dermatol 115: 130-1 14. Peters EM, Tobin DJ, Seidah NG, Schallreuter
KU (2000) Pro-opiomelanocortin-related peptides, prohormone convertases
1 and 2 and the regulatory peptide 7B2 are present in melanosomes of
human melanocytes.
J Invest Dermatol 114: 430-7 15. Schallreuter
KU,
Wood
JM
(2001) Thioredoxin reductase - its role in epidermal redox
status. J Photochem Photobiol B 64: 179-84 16. Schallreuter KU, Moore J,
Wood JM et al. (2001) Epidermal H2O2
accumulation alters tetrahydrobiopterin (6BH4) recycling in
vitiligo: identification of a general mechanism in regulation of all 6BH4-dependent
processes?
J Invest
Dermatol 116: 167-74 17. Schallreuter
KU,
Moore
J,
Behrens-Williams S, Panske A, Harari M (2002) Rapid
initiation of repigmentation in vitiligo with Dead Sea climatotherapy
in combination with pseudocatalase (PC-KUS). Int J Dermatol 41: 482-7 18. Schallreuter
KU,
Tobin
DJ,
Panske A (2002) Decreased photodamage and low incidence
of non-melanoma skin cancer in 136 sun-exposed caucasian patients with
vitiligo. Dermatology 204: 194-201 19. Rokos
H,
Beazley
WD,
Schallreuter KU (2002) Oxidative stress in vitiligo:
photo-oxidation of pterins produces H2O2 and
pterin-6-carboxylic acid. Biochem Biophys Res Commun 292: 805-11 20. Moore
J,
Wood
JM,
Schallreuter KU (2002) H2O2-mediated
oxidation of tetrahydrobiopterin: Fourier transform Raman
investigations provide mechanistic implications for the enzymatic
utilization and recycling of this essential co-factor. J Raman
Spectrosc 33: 610-617 21. Schallreuter KU, Moore J,
Behrens-Williams S et al. (2002) In vitro and in vivo identification of
Pseudocatalase activity in Dead Sea water using Fourier Transform Raman
Spectroscopy. J Raman Spectrosc 33: 586-592 22. Marles
LK,
Peters
EM,
Tobin DJ, Hibberts NA, Schallreuter KU (2003) Tyrosine
hydroxylase isoenzyme I is present in human melanosomes: a possible
novel function in pigmentation. Exp Dermatol 12: 61-70 23. Schallreuter
KU,
Behrens-Williams
S,
Khaliq TP et al. (2003) Increased epidermal
functioning wild-type p53 expression in vitiligo. Exp Dermatol 12: 268-277 24. Schallreuter
KU,
Kothari
S,
Hasse S et al. (2003) In situ and in vitro evidence for
DCoH/HNF-1 alpha transcription of tyrosinase in human skin melanocytes.
Biochem Biophys Res Commun 301: 610-616 25. Kauser S, Schallreuter KU, Thody AJ, Gummer C,
Tobin DJ (2003) Regulation of Human Epidermal Melanocyte Biology By
beta-Endorphin. J
Invest Dermatol 120: 1073-1080 26. Schallreuter
KU
(2003)
Effectiveness
of pseudocatalase formulations in vitiligo.
Clin Exp Dermatol 28: 1-2 27. Schallreuter KU, Kothari S, Elwary S, Rokos H,
Hasse S, Panske A (2003) Molecular evidence that halo in Sutton's
naevus is not vitiligo. Arch Dermatol Res 295: 223-228 28. Rokos
H,
Moore
J,
Hasse S, Gillbro JM, Wood JM, Schallreuter KU (2004) In
vivo Fluorescence Excitation Spectroscopy and in vivo
FT-Raman Spectroscopy in human skin: Evidence
of H2O2 oxidation of epidermal albumin in
patients with vitiligo. J Raman Spectrosc 35: 125-130 29. Schallreuter
KU,
Elwary
SM,
Gibbons NC, Rokos H, Wood JM (2004)
Activation/deactivation of acetylcholinesterase by H2O2:
more
evidence
for
oxidative stress in vitiligo. Biochem Biophys Res
Commun 315: 502-508 30. Hasse S, Gibbons NC, Rokos H, Marles LK,
Schallreuter KU (2004) Perturbed 6-tetrahydrobiopterin recycling via
decreased dihydropteridine reductase in vitiligo: more evidence for H2O2
stress. J Invest
Dermatol 122: 307-313 31. Elwary SM, Hasse S, Schallreuter KU (2004) m2
muscarinic acetylcholine receptor (mAchR) subtype is present in human
epidermal keratinocytes in situ and in vivo. J Invest Dermatol 123: 1206-7 32. Wood
JM,
Chavan
B,
Hafeez I, Schallreuter KU (2004) Regulation of tyrosinase
by tetrahydropteridines and H2O2. Biochem Biophys
Res Commun 325: 1412-7 33. Kurzen
H,
Schallreuter
KU
(2004) Novel aspects in cutaneous biology of
acetylcholine synthesis and acetylcholine receptors. Exp Dermatol 13
Suppl 4: 27-30 34. Schallreuter
KU,
Wazir
U,
Kothari S, Gibbons NC, Moore J, Wood JM (2004) Human
phenylalanine hydroxylase is activated by H2O2: a
novel mechanism for increasing the L-tyrosine supply for melanogenesis
in melanocytes. Biochem Biophys Res Commun 322: 88-92 35. Gillbro JM, Marles LK, Hibberts NA,
Schallreuter KU (2004) Autocrine catecholamine biosynthesis and the
beta-adrenoceptor signal promote pigmentation in human epidermal
melanocytes. J
Invest Dermatol 123: 346-53 36. Kauser S, Thody AJ, Schallreuter KU, Gummer
CL, Tobin DJ (2004) beta-Endorphin as a regulator of human hair
follicle melanocyte biology. J Invest Dermatol 123: 184-95 37. Schallreuter
KU.
Basic
Research:
An Update. In: Lotti T, Hercogova J, eds. Vitiligo.
Problems and Solutions. New York: Marcel Decker, 2004: 65-78. 38. Kauser
S,
Thody
AJ,
Schallreuter KU, Gummer CL, Tobin DJ (2005) A fully
functional proopiomelanocortin/melanocortin-1 receptor system regulates
the differentiation of human scalp hair follicle melanocytes.
Endocrinology 146: 532-43 39. Hasse
S,
Kothari
S,
Rokos H, Kauser S, Schürer NY, Schallreuter KU (2005) In
vivo and in vitro evidence for
autocrine DCoH/HNF-1alpha transcription of albumin in the human
epidermis. Exp Dermatol 14: 182-7 40. Schallreuter
KU,
Elwary
S,
Gibbons N, Rokos H, Wood JM (2005) Human epidermal
acetylcholinesterase (AchE) is regulated by hydrogen peroxide (H2O2).
Exp
Dermatol
14: 155 41. Slominski
A,
Wortsman
J,
Plonka PM, Schallreuter KU, Paus R, Tobin DJ (2005) Hair
follicle pigmentation. J Invest Dermatol 124: 13-21 42. Schallreuter KU. Vitiligo.
In: Hertl M, ed. Autoimmune
Diseases of the Skin. Pathogenesis,
Diagnosis,
Management.
2nd
ed. Wien: Springer, 2005: 367-384. 43. Wood JM, Chavan B, Hafeez I, Schallreuter KU
(2005) Regulation of tyrosinase by tetrahydropteridines-What is real? A
critical reanalysis of H. Wojtasek's view. Biochem Biophys Res Commun 331: 891-3 44. Schallreuter
KU,
Chavan
B,
Rokos H, Hibberts N, Panske A, Wood JM (2005) Decreased
phenylalanine uptake and turnover in patients with vitiligo. Mol Genet
Metab 86 Suppl 1: S27-33 45. Spencer JD, Chavan B, Marles LK, Kauser S, Rokos H, Schallreuter KU (2005) A novel mechanism in control of human pigmentation by {beta}-melanocyte-stimulating hormone and 7-tetrahydrobiopterin. J Endocrinol 187: 293-302 46. Schallreuter
KU
(2005)
Oxidative
stress in the human epidermis. G Ital Dermatol
Venereol 140: 505-14 47. Wood
JM,
Schallreuter
KU
(2006) UVA-irradiated pheomelanin alters the
structure of catalase and decreases its activity in human skin. J
Invest Dermatol 126: 13-4 48. Schallreuter
KU,
Rübsam
K,
Chavan B et al. (2006) Functioning methionine sulfoxide
reductases A and B are present in human epidermal melanocytes in the
cytosol and in the nucleus. Biochem Biophys Res Commun 342:
145-52 49. Schallreuter
KU
(2006)
Functioning
methionine-S-sulfoxide reductases A and B are
present in human skin. J Invest Dermatol 126: 947-9 50. Schallreuter
KU,
Chiuchiarelli
G,
Cemeli E et al. (2006) Estrogens can contribute to
hydrogen peroxide generation and quinone-mediated DNA damage in
peripheral blood lymphocytes from patients with vitiligo. J Invest
Dermatol 126: 1036-42 51. Schallreuter
KU,
Rokos
H
(2006) Turmeric (curcumin): a widely used curry ingredient,
can contribute to oxidative stress in Asian patients with acute
vitiligo. Indian J Dermatol Venereol Leprol 72: 57-9 52. Hoogduijn
MJ,
Hitchcock
IS,
Smit NP, Gillbro JM, Schallreuter KU, Genever PG
(2006) Glutamate receptors on human melanocytes regulate the expression
of MiTF. Pigment Cell Res 19: 58-67 53. Elwary
SM,
Chavan
B,
Schallreuter KU (2006) The vesicular acetylcholine
transporter is present in melanocytes and keratinocytes in the human
epidermis. J Invest Dermatol 126: 1879-84 54. Wood
JM,
Gibbons
NC,
Schallreuter KU (2006) Melanocortins in human
melanocytes. Cell Mol Biol (Noisy-le-grand) 52: 75-8 55. Schallreuter
KU,
Gibbons
NCJ,
Zothner C, Elwary SM, Rokos H, Wood JM (2006)
Butyrylcholinesterase is present in the human epidermis and is
regulated by H2O2: More evidence for oxidative
stress in vitiligo. Biochem Biophys Res Commun 349: 931-8 56. Pey AL, Martinez A, Charubala R et al. (2006) Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo. Faseb J 20: 2130-2 57. Chavan B, Gillbro JM, Rokos H, Schallreuter KU (2006) GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. J Invest Dermatol 126: 2481-9 58. Schallreuter KU, Gibbons NCJ, Rokos H, Rübsam K, Wood JM (2006) Hydrogen peroxide mediated oxidation severely compromises the methionine sulfoxide A / thioredoxin reductase antioxidant defence system. J Invest Dermatol 126 Suppl 3: Abstract 77 59. Gibbons NCJ, Wood JM, Rokos H, Schallreuter KU (2006) Computer simulation of native epidermal enzyme structures in the presence and absence of hydrogen peroxide (H2O2): Potential and pitfalls. J Invest Dermatol 126: 2576-2582 60. Gillbro JM, Gibbons NCJ, Chavan B, Pittelkow MP, Wood JM, Schallreuter KU (2007) Regulation of the b2-adrenergic receptor by tetrahydrobiopterin (6BH4). In: Peters GJ, Jansen G, eds. Chemistry and Biology of Pteridines and Folates Heilbronn: SPS Verlagsgesellschaft, 408-422. 61. Spencer JD, Chavan B, Marles LK, Rokos H, Schallreuter KU (2007) Identification of a physiological role for 7BH4 in human melanogenesis. In: Peters GJ, Jansen G, eds. Chemistry and Biology of Pteridines and Folates. Heilbronn: SPS Verlagsgesellschaft, 397-407. 62. Schallreuter KU, Gibbons NC, Elwary SM, Parkin SM, Wood JM (2007) Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates. Biochem Biophys Res Commun 355: 1069-74 63. Spencer JD, Gibbons NCJ, Rokos H, Peters EMJ, Wood JM, Schallreuter KU (2007) Oxidative stress via hydrogen peroxide affects proopiomelanocortin-peptides directly in the epidermis of patients with vitiligo. J Invest Dermatol 127: 411-20 64. Schallreuter KU, Elwary S (2007) Hydrogen peroxide regulates the cholinergic signal in a concentration dependent manner. Life Sci 80: 2221-6 65. Schallreuter KU, Rokos H (2007) From the bench to the bedside: proton pump inhibitors can worsen vitiligo. Br J Dermatol 156: 1371-3 66. Schallreuter KU (2007) Advances in melanocyte basic science research. Dermatol Clin 25: 283-91 67. Schallreuter KU, Gibbons NC, Zothner C, Abou Elloof MM, Wood JM (2007) Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 360: 70-5 68. Schallreuter KU, Krüger C, Rokos H, Hasse S, Zothner C, Panske A (2007) Basic research confirms coexistence of acquired Blaschkolinear Vitiligo and acrofacial Vitiligo. Arch Dermatol Res 299: 225-30 69. Schallreuter KU, Wei Y, Pittelkow MR, Swanson NN, Gibbons NC, Wood JM (2007) Structural and functional alterations in the beta2-adrenoceptor are caused by a point mutation in patients with atopic eczema. Exp Dermatol 16: 807-13 70. Schallreuter KU, Bahadoran P, Picardo M et al. (2008) Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Dermatol 17: 139-40; discussion 141-60 71. Schallreuter KU, Kothari S, Chavan B, Spencer JD (2008) Regulation of melanogenesis--controversies and new concepts. Exp Dermatol 17: 395-404 72. Schallreuter KU, Rokos H, Chavan B et al. (2008) Quinones are reduced by 6-tetrahydrobiopterin in human keratinocytes, melanocytes, and melanoma cells. Free Radic Biol Med 44: 538-46 73. Shalbaf M, Gibbons NC, Wood JM et al. (2008) Presence of epidermal allantoin further supports oxidative stress in vitiligo. Exp Dermatol 17(9): 761-70 74.
Spencer JD, Gibbons NC, Böhm M, Schallreuter KU (2008) The Ca2+-binding
capacity
of
epidermal
furin is disrupted by 75. Wood JM, Gibbons NC, Chavan B, Schallreuter KU (2008) Computer simulation of heterogeneous single nucleotide polymorphisms in the catalase gene indicates structural changes in the enzyme active site, NADPH-binding and tetramerization domains: a genetic predisposition for an altered catalase in patients with vitiligo? Exp Dermatol 17: 366-71 76. Schallreuter KU, Rübsam K, Gibbons NC et al. (2008) Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo. J Invest Dermatol 128: 808-15 77. Wood JM, Schallreuter KU (2008) A plaidoyer for cutaneous enzymology: our view of some important unanswered questions on the contributions of selected key enzymes to epidermal homeostasis. Exp Dermatol 17: 569-578 78. Rokos H, Wood JM, Hasse S, Schallreuter KU (2008) Identification of epidermal L-tryptophan and its oxidation products by in vivo FT-Raman Spectroscopy further supports oxidative stress in patients with vitiligo. J Raman Spectrosc 39: 1214-1218 79.
Plonka PM, Passeron T, Brenner M et al. (2009) What are
melanocytes really doing all day long...? Exp Dermatol 18: 799-819 80. Chavan B,
Beazley
W, Wood JM,
Rokos H, Ichinose H, Schallreuter KU (2009) H2O2
increases de novo synthesis of
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and
its feedback regulatory protein in vitiligo. J Inherit Metab Dis 32:
86-94 81.
Salem MM, Shalbaf
M, Gibbons NC, Chavan B, Thornton JM, Schallreuter KU (2009) Enhanced
DNA binding capacity on up-regulated epidermal wild-type p53 in
vitiligo by H2O2-mediated oxidation: a possible
repair mechanism for DNA damage. Faseb J 23:
3790-807 82.
Schallreuter KU, Hasse S, Rokos H et al. (2009) Cholesterol
regulates melanogenesis in human epidermal melanocytes and melanoma
cells. Exp Dermatol 18: 680-8 83.
Spencer JD,
Schallreuter KU (2009) Regulation of pigmentation in human epidermal
melanocytes by functional high-affinity beta-melanocyte-stimulating
hormone/melanocortin-4 receptor signaling. Endocrinology 150: 1250-8 84.
Vafaee T, Rokos H,
Salem MM, Schallreuter KU (2010) In vivo and in vitro evidence for
epidermal H2O2-mediated oxidative stress in
piebaldism. Exp Dermatol 19(10): 883-7, epub Sep 16 2009 85. Wood
JM,
Decker
H,
Hartmann H et al. (2009) Senile hair graying: H2O2-mediated
oxidative
stress
affects
human hair color by blunting methionine
sulfoxide repair. Faseb J 23: 2065-75 86. Schallreuter KU,
Salem MM (2010) Vitiligo. Was ist neu? Hautarzt Jul. 61(7): 578-85 87. Mastrofrancesco A,
Kokot A, Eberle A, Gibbons NC, Schallreuter KU, Strozyk E, Picardo M,
Zouboulis CC, Luger TA, Böhm M (2010) KdPT, a tripeptide derivate of
alpha-melanocyte-stimulating hormone, suppresses IL-1 beta-mediated
cytokine expression and signaling in human sebocytes. J Immunol Aug. 1,
185(3): 1903-11 88. Schallreuter KU,
Salem MM, Hasse S, Rokos H (2010) The redox-biochemistry of human hair
pigmentation. Pigment Cell Melanoma Res. Oct 19 epub ahead of
publication 89. Krüger C, Smythe
JW, Spencer JD, Hasse S, Panske A, Chiuchiarelli G, Schallreuter KU
(2011) Significant immediate and long-term improvement in quality of
life and disease coping in patients with vitiligo after group
climatotherapy at the Dead Sea. Acta Derm Venereol. Jan 17 (Epub ahead
of print)
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